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A 2022 study published in Diabetes, Obesity and Metabolism found that adults over 50 achieved clinically significant weight loss on semaglutide, with cardiovascular and metabolic risk reductions comparable to younger cohorts, though the authors noted the importance of individualized monitoring protocols for older patients given the higher baseline prevalence of comorbidities

(2015) treated 50 sudden deafness patients with subperiosteal methylprednisolone injections every 3 days (5 total injections) and found a 70% overall response rate

It was FDA-approved for obesity in 2014

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We did not include achievement of at least a 5% reduction in body weight as an outcome because all doses of both drugs were superior to placebo in achieving at least a 10% weight reduction

The inhibitory effect of glucagon-like peptide-1 (GLP-1) 7-36 amide on gastric acid secretion in humans depends on an intact vagal innervation