You may experience a temporary return of appetite during the gap, which is normal
For dual agonists: because they are stronger, the sideeffect profile may be similar or somewhat amplified

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Semaglutide-induced hepatic injury: A rare case of drug-induced liver injury
In vivo anti-psoriatic studies In vivo anti-psoriatic efficacy IMQ, a Toll-like Receptor 7 and 8 (TLR7/8) ligand, is a potent immune activator