Se also reduces the incidence of autoimmune thyroiditis and other related conditions, and the reduction of thyroid autoimmune effects is related to the role of GPX and thioredoxin reductase (TrxR) as antioxidant defense systems that scavenge ROS and excess H 2 O 2 produced by thyroid cells during thyroid hormone synthesis, which can lead to thyroid cell necrosis and increased macrophage invasion in severe nutritional Se deficiency (Duntas, 2006)
The roles of epigallocatechin gallate in the tumor microenvironment, metabolic reprogramming, and immunotherapy
mPFC is a key region involved in executive function and adaptive behavior and appears important for aspects of social cognition, including theory of mind(Zhang et al., 2021), all commonly different in autism
Gut microbes can also convert 2-methylbutyric acid (2MBA) to 2-methylbutyrylcarnitine (2-MBC)
Course-based, predictable, far less risk
Metabolic byproducts such as 2-deoxy-D-ribose also trigger ferroptosis by degrading the core subunit of System Xc (xCT) and consuming GSH (Kim et al., 2023)