Notably, Thr is known to be critical for the generation of SAM during in vitro reprogramming and in the maintenance of pluripotent cells 12,34,35
10.1016/j.biocel.2014.05.016 Int J Biochem Cell Biol
[7] S-adenosylmethionine synthetase, C terminal domain [edit] In molecular biology, the protein domain S-adenosylmethionine synthetase, C-terminal domain refers to the C terminus of the S-adenosylmethionine synthetase C terminal domain function [edit] The function of the C-terminal domain has been experimentally determined as being important for cytoplasmic localisation
Preclinical and translational studies have examined these peptide classes in models related to endocrine regulation, metabolism, and recovery oriented research questions, with outcomes dependent on study design and assays used
Notably, the highest dose tested (54 mg) showed increased gastrointestinal event frequency compared to lower doses, suggesting a dose-relationship for this effect category
doi: 10.1016/j.freeradbiomed.2025.05.431 110 MarchiSPatergnaniSMissiroliSMorcianoGRimessiAWieckowskiMRet al