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The practical differences often come down to individual tolerance, availability, insurance coverage, and the specific indication (diabetes versus obesity)
Consistent with these theoretical notions, alternative fuels, metabolic supplements and mitochondrial function enhancers have been investigated with the purpose of improving ALS symptoms and delaying disease progression in mouse models of ALS, cell cultures and in patients with ALS
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Dose ranges are often species- and model-dependent, with rodent studies using body-weight-normalized doses (mcg/kg or mg/kg) that may be substantially different from the fixed doses used in primate or pharmacokinetic models
