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muscle weakness
Key molecular mechanisms encompass oxidative modification of critical proteins leading to dysfunction [361], membrane lipid peroxidation disrupting organelle integrity [362], mtDNA damage causing mitochondrial dysfunction [363], and depletion of key antioxidant molecules [364]
Faster initial weight loss may reflect water loss or aggressive calorie restriction, which can be difficult to maintain
"Constipation from GLP-1s can be compounded by the fact that people are eating less," says Hamilton, "resulting often in less fiber consumption and less stool bulk overall." Many people also drink less fluid to avoid feeling overly full on GLP-1 medications, which can also lead to constipation