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Studies have shown that Complex I activity is diminished in both post-mortem brain tissue and peripheral blood cells of PD patients ( Previous studies have shown that mitochondrial dysfunction related to PD can be caused by various factors, including mitochondrial bio-genetic defects, increased ROS production, mitophagy defects, transport disorders, electron transport chain dysfunction, mitochondrial dynamics changes, and mitochondrial calcium imbalance

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APRI: AST-to-platelet ratio index

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They are not fertility drugs, and they should not be used during pregnancy unless a qualified clinician specifically advises otherwise