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GSH depletion can trigger ferroptosis, which has been exploited in cancer treatments [17], and supplementation with GSH is utilized by glutathione peroxidase 4 (GPX4) to prevent lipid peroxidation, in turn inhibiting ferroptosis
Thus, the combined administration of hepsin with NAC optimized the therapeutic outcome, enhancing effectiveness beyond what was achievable with NAC alone
PMID 24748564
J Mater Chem 22:470477 Chen S-S, Xu X-F, Deng W-Q, Mao G-J, Hu L, Ouyang J et al (2024) An ATP-responsive ZIF-based NIR fluorescence nanosystem for enhanced chemo-photodynamic therapy of tumors
Quicksilver Delivery Systems protects glutathione from breakdown in the digestive system that otherwise prevents absorption of oral glutathione supplementation.* In addition to greatly improving bioavailability, the liposomal delivery format enables intracellular delivery of glutathione
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