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How GLP-1 and GIP Receptors Influence Brain Function and Mood GLP-1 receptors are present in brain regions involved in appetite control, reward processing, and mood regulationspecifically the hypothalamus and parts of the prefrontal cortex

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Central administration of Ucn1 also suppresses feeding, and its effect is strongest in the PVN and more potent and longer-lasting than that of CRF

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