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Importantly, these medications are not generally recommended in patients with severe gastrointestinal disease, including severe gastroparesis, which may be relevant when considering their use in individuals with Crohn's disease

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Fourth - and most time-sensitive: the FDA published a proposed rule on April 30, 2026 proposing to exclude semaglutide and tirzepatide from the 503B Bulks List, with a public comment period closing June 29, 2026

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Supply-demand comparison. On the substance, Grossman painted a picture of an agency that took the manufacturers spreadsheets at face value