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Phase 3 Trial Deep Dive I pulled the primary publications for each pivotal trial and summarized the design and findings below
Notable gastrointestinal side effects include: Constipation Diarrhea Abdominal pain Pancreatitis Gallbladder disease Despite side effects being found mainly in the stomach and intestines, gallstones and pancreatitis can result in perceived muscle aches and medication-related Ozempic back pain
Gastric Bypass Often has a strong metabolic effect, especially for type 2 diabetes
But we sometimes also add in things like creatine, amino acids, and other targeted supplements to help promote muscle health
doi: 10.1038/s41598-021-00802-9 64 DierUShinDHHemachandraLPUusitaloLMHempelN
nejm.org/doi/full/10.10 Tirzepatide was the first dual GLP-1 and glucose-dependent insulinotropic peptide receptor agonist approved for the treatment of type 2 diabetes on the basis of the SURPASS-1 (Tirzepatide [LY3298176] in Participants with Type 2 Diabetes Not Controlled with Diet and Exercise Alone) trial, a randomized, placebo-controlled trial of tirzepatide (administered in weekly doses of 5 mg, 10 mg, or 15 mg) paired with metformin for treatment of type 2 diabetes (seen in figure)
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