Like liraglutide, semaglutide incorporates an Aib substitution at the 8th position in place of Ala, which confers resistance to enzymatic degradation by DPP-4
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PubMed laboratory research record [PMID: 17956796] PubMed record related to this compound for laboratory literature review
This effect goes via NO-mediated and cholinergic mechanisms (Kokot et al., 2016), which were accepted as key in ophthalmic arterial dilatation (Osborne et al., 2004)
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Because the medication reduces appetite significantly, there is a risk of inadequate nutrient intake if meals are not carefully planned