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GLP-1s are great, but it looks like people cant stay on them forever, says James Hamilton, Arrowheads chief medical officer

After 12 weeks, cycle off Tesamorelin for 4 weeks (standard protocol), and you can choose to continue or pause MOTS-C

There were some limitations on the study: The larger trial wasn't focused on heart failure per se, so another trial that does focus on this type of patient is needed, Deanfield and his team believe

They act on the brain to tell us we are full and to decrease appetite, says Fatima Cody Stanford, an obesity physician at Massachusetts General Hospital and Harvard Medical School, US

There's also a body-composition angle

Bertoncello et al