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1 x Composite major CV events were analyzed in a time-to-first-event analysis with a Cox proportional-hazards model with treatment as a categorical fixed factor and stratified according to SGLT-2i use as baseline

1 2 3 4 5 Molecular Neuropharmacology: A Foundation for Clinical Neuroscience (2nd ed.)

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Tirzepatide produced even larger and dose-dependent weight losses, with many participants losing more than 20% of their body weight, the results that were historically only bariatric surgery achieved

They suspected that the phenomenon might be down to a substance in the gut like 'the hypothetical incretin' (Samols, Marri, Marks 1966