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EP: Conceptualization, Methodology, Writing review & editing
Quick Answer: Semaglutide improves insulin sensitivity primarily through significant weight loss and enhanced glycemic control rather than direct insulin-sensitizing effects
Individual components suit studies that need to isolate a specific mechanism or control for individual compound contributions to observed outcomes
However, it is essential to note that the higher-dose formulation of semaglutide, Wegovy, is specifically designed and approved for obesity treatment
2021, NEJM) for Wegovy or SURMOUNT-1 (Jastreboff et al
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