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ROS and oxidatively modified macromolecules function as damage-associated molecular patterns (DAMPs), engaging pattern recognition receptors (PRRs) on microglia, including Toll-like receptors (TLRs) and NOD-like receptors (NLRs), to initiate inflammatory cascades ( Microglia, the resident immune cells of the CNS, are tightly regulated under physiological conditions to maintain neural homeostasis
Less Sunlight Makes Hormones Go Off-Beat In winter, especially December and January, days are shorter, and sunlight is limited
Anti-Inflammatory Actions Chronic inflammation drives tissue degradation and interferes with proper healing
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These are unstructured bursts of movement during normal life: chasing your kid, sprinting upstairs, walking fast to catch a bus Researchers measured this with wrist accelerometers, not self-report questionnaires
2076-2084, (2016) (PubMed)
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