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Recent research has added another layer of complexity

Quick Answer: Most semaglutide side effects, particularly gastrointestinal symptoms like nausea, typically peak within 48 weeks and gradually improve over 23 months as tolerance develops

Practical precautions for people with diabetes: never drink on an empty stomach, check blood glucose before and after drinking and before bed, be aware that hypoglycemia symptoms (confusion, slurred speech, unsteadiness) overlap with intoxication symptoms, and tell someone you are with what to watch for

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Carretero Gmez J, Ena J, Segu Ripoll JM et al (2020) Early biomarkers of diabetic kidney disease

doi:10.1002/14651858.CD008955.pub2