Tesamorelin acetate is a synthetic 44-amino-acid peptide analog of human growth hormone-releasing hormone (GHRH), with the sequence trans-3-hexenoyl-Tyr-D-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr-Arg-Lys-Val-Leu-Ala-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Met-Ser-Arg-Gln-Gln-Gly-Glu-Ser-Asn-Gln-Glu-Arg-Gly-Ala-Arg-Ala-Arg-Leu-NH2.[1][2] It has a molecular weight of approximately 5136 Da and a half-life of about 26-38 minutes, supporting daily subcutaneous administration.[3][4] FDA-approved in 2010 as Egrifta for reducing excess abdominal fat in HIV-infected patients with lipodystrophy, it is available as a branded product but can be compounded for specific needs under regulations.[5][6] Key characteristics for compounding pharmacies include: Stabilized Structure : N-terminal modification enhances stability and activity compared to native GHRH.[1][7] Lyophilized Form : Supplied as a powder for reconstitution, ensuring sterility.[8][9] Versatile Delivery : Primarily subcutaneous, with potential for customized concentrations.[10][11] This makes Tesamorelin suitable for precise preparations in compounding settings
It showed similar results: participants who took the drug lost an average of 15 percent of body weight lost, whereas those who took the placebo lost an average of just 2.4 percent
10.1016/j.jtcvs.2005.06.015 J
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