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When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount

134 , 1558S1565S (2004)

Fc-based bsAbs have homo- or heterodimeric Fc domains (and less frequently CH3 domains only) to which Fab, scFv or sdAb are attached through a peptide linker [20]

Significant targets and the effects of PKGI in SMC are activation of myosin light chain phosphatase, inhibition of PLC, inhibition of the IP 3 receptor, inhibition of plasma membrane localized L-type Ca 2+ channels, and activation of plasma membrane localized calcium-activated K + channels (commonly called the big potassium, BK, channels)

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