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doi: 10.1007/s11064-017-2288-7

These agents act on pathways of the brain that regulate weight and food intake, and when these patients are no longer receiving treatment, they no longer have these brain pathways to regulate weight, and they regain it, she says

Not valid with all surgeons and may be based on availability

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Mechanisms of Benefit Weight LossMediated: The predominant proposed mechanism is indirect: weight loss reduces adipose-derived pro-inflammatory cytokine secretion, lowers systemic IL-6, TNF-, and IL-17 levels, improves insulin sensitivity, and reduces the immunological "noise" that drives psoriatic inflammation