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Figure 3 Tumor Necrosis Factor Both TNF and IL-6 are correlated with the body mass index (BMI), and TNF is known to play a role in obesity and in particular in the insulin resistance and diabetes that often accompany obesity ( Tumor necrosis factor is a therapeutic target in several diseases and anti-TNF treatment is successfully applied in rheumatoid arthritis, psoriasis, ankylosing spondylitis, and IBD

By the middle of the twentieth century, the idea of redox coupling between ascorbate and glutathione had been proposed by several researchers