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Vas de sealizacin documentadas en literatura: Activacin de telomerasa (hTERT): modelos celulares documentan induccin de actividad telomerasa y elongacin de telmeros en fibroblastos humanos en cultivo Modulacin circadiana: estudios preclnicos en roedores describen normalizacin de la secrecin de melatonina y del ritmo circadiano Regulacin gnica / cromatina: literatura experimental reporta efectos sobre la expresin gnica y la estructura de la cromatina (heterocromatina perinuclear) EVIDENCIA CIENTFICA DOCUMENTADA Khavinson VK et al., Neuro Endocrinol Lett 2003 (PMID 14523363): Epithalon en modelos de envejecimiento celular y activacin de telomerasa Anisimov VN et al., Mech Ageing Dev 2003 (PMID 12782392): Epithalon en modelos murinos de longevidad y carcinognesis Khavinson VK, Bull Exp Biol Med 2002 (PMID 12937682): efectos del tetrapptido sobre la actividad telomerasa en cultivos celulares humanos Material de investigacin nicamente

The PfGrx C32S/C88S (SSG)-dependent oxidation of roGFP2 WT or glutathionylation of both monothiol roGFP2 variants were accelerated at increasing glutaredoxin concentrations and followed pseudo-first-order kinetics (Fig

Life-threatening internal bleeding can be a very serious complication in children with thrombocytopenia