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Orforglipron significantly reduced HbA1c to 2.1% in a phase II clinical trial assessing its use in T2DM, while dulaglutide achieved 1.1% and a placebo achieved 0.43% [106]
[1] [3] After subcutaneous injection, semaglutide is absorbed slowly and reaches peak plasma concentrations in one to three days
Some may even carry risks without delivering meaningful benefits
But issues can arise e.g., impurities, immunogenicity to cause concern
Liu L, Li Z, Ye W, et al
But while many articles hold the GLP-1s as magical compounds, others decry them for various reasons (which all fundamentally come down to rationalizing moralistic beliefs about overweight and obesity)
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