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Adiponectin signaling suppresses vascular cell adhesion molecule-1 (VCAM-1) expression and maintains claudin-5 expression, whereas adiponectin deficiency exacerbates vascular leakage and endothelial inflammation (142144, 146)

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Mechanism of Action: The elevator pitch for the ketogenic diet[iii] typically involves reducing carbohydrate intake to less than 25 grams per day, leading to a state of ketosis where the body relies on fat as its primary energy source

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