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Standard rapid-release formulas, even if absorbed, create a brief spike in blood levels followed by a rapid crash, whereas sustained-release formulations maintain a therapeutic window that provides round-the-clock cellular protection
If intolerable side effects occur during escalation, remain at current dose for an additional 4 weeks before attempting to increase, or drop back to the previous dose
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Sterile ELISPOT plates with a PVDF membrane (Millipore Corp, Bedford, MA, USA) were coated with anti-human IgG (15 g/mL, Mabtech, Nacka Strand, Sweden) overnight at 4C
Use the supplement with caution
IL-2 can be used to treat advanced melanoma, although checkpoint inhibitors are used more because they are effective and tend to have fewer side effects
