HIV-1 Nef promotes ubiquitination and proteasomal degradation of p53 tumor suppressor protein by using E6AP
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In those reports, most cases stemmed from therapeutic errors, and patients typically experienced no symptoms or only mild effects such as nausea, vomiting, abdominal pain, or weakness, with the majority managed safely at home without hospitalization [23, 24]
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Still, the large, multinational dataset and consistent findings across sensitivity analyses strengthen the conclusions