This happens for several reasons that are all completely normal
In addition to reducing or eliminating the symptoms of B12 deficiency, research suggests that B12 shots may: Reduce stress (7) Support central nervous system function, red blood cell formation, and DNA synthesis (2) Reduce the risk of vision loss from age-related macular degeneration (8) Lower homocysteine levels, which is associated with cardiovascular disease and stroke (9, 10)
Aksoy S, Szumlanski CL, Weinshilboum RM
(PubMed) Hammoud AO, Bujold E, Sorokin Y, Schild C, Krapp M, Baumann P
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Alternate between your abdomen, thigh, and upper arm to reduce irritation and allow each site to recover