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Side effects, although present, are typically mild

Most occur during the first 4 to 8 weeks on each new dose tier, then taper as the GI tract adapts

How GLP-1 Receptor Agonists Work Native GLP-1 has a short half-life of just 1-2 minutes because it is rapidly broken down in the blood by the enzyme dipeptidyl peptidase 4 (DPP-4)

Semaglutide is a glucagon-like peptide-1 (GLP-1) receptor agonist approved by the FDA for type 2 diabetes management (under the brand names Ozempic and Rybelsus) and chronic weight management (Wegovy)

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Prog Nucl Magn Reson Spectrosc 109:150 Lapidus KA, Gabbay V, Mao X et al (2014) In vivo (1)H MRS study of potential associations between glutathione, oxidative stress and anhedonia in major depressive disorder