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Tang AH and Tu CP

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GLP-1 is post-translationally cleaved from the product of the proglucagon gene (GCG) by prohormone convertase (PC) enzymes 1/3 (PCSK1/3)

It may be producing milk for a growing infant

They are indicated for type 2 diabetes management, weight reduction in obesity, and cardiovascular risk reduction, with ongoing investigation into metabolic dysfunction-associated steatohepatitis, chronic kidney disease, and heart failure with preserved ejection fraction

In the context of bariatric surgery, rats lacking melanocortin 4 receptors (MC4Rs), which are activated by the POMC-cleavage product alpha-MSH [157], are still responsive to VSG [158]