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Combined Approach Timeline When using both together, many people report seeing initial brightness improvements within 2-3 weeks, with more dramatic skin tone changes developing over 2-3 months

Retatrutide: A triple agonist (GLP-1/GIP/glucagon) currently in phase 3 trials

Semaglutide is a modified peptide consisting of 31 amino acids, designed to have a longer duration of action than the body's natural GLP-1, which is rapidly broken down by enzymes

Furthermore, in January 2025, the FDA approved semaglutide (Ozempic ) for reducing the risk of kidney failure and disease progression in patients with diabetes and chronic kidney disease (CKD), making it the first GLP-1 agent indicated for the treatment of CKD (Perkovic et al., 2024)

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