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However, several drugs, including teprotumumab and BIIB-022, which target IGF-1R, have not shown good therapeutic effects in clinical trials, possibly due to the lack of reliable IGF-1R inhibition biomarkers

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Many teams also build in a washout period at the end of a study before any follow-up dosing phase, giving the GH axis time to return to baseline and reducing the risk of carryover effects confounding a subsequent phase

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Many studies examine isolated mechanisms rather than long-term patient outcomes