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Injection of preformed -syn fibrils in mice induced pathological changes, leading to impaired meningeal lymphatic drainage, loss of endothelial tight junctions, and increased meningeal inflammation [176]

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Despite research reporting physiological potential similar to the parent protein, Receptor Grade IGF-1 LR3 does not appear to interact with IGF binding proteins (IGFBPs) as strongly as IGF-1

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