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6.1.2 NLRP3 inflammasome inhibitors The NLRP3 inflammasome is a multiprotein complex that becomes activated following ischemic stroke, promoting the maturation and release of IL-1 and IL-18, thereby exacerbating neuroinflammation (221)
Leptin is essential for the hepatic fibrogenic response to chronic liver injury
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Saxena D, Maitra R, Bormon R, et al
Pfizer (eliminated): The discontinuation of danuglipron in April 2025 eliminated the most advanced competing oral small-molecule GLP-1 program
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