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Since CD163 does not uptake dimeric Hb without Hp during acute hemolysis, the survival advantage and enhanced HO-1 expression may suggest novel cellular uptake routes for either Hb dimer, heme, or both
Written By: Pharmacally medical News Desk The New England Journal of Medicine has published results from the SURPASS-CVOT trial (NCT04255433), a landmark cardiovascular outcomes study evaluating tirzepatide in people with type 2 diabetes and established atherosclerotic cardiovascular disease
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Patients whose diabetes is being managed with the support of semaglutide (sold as Ozempic) are likely to again encounter issues accessing the medication due to ongoing stock shortages
However, considering that the safety and tolerability profile of oral semaglutide in PIONEER 12 was consistent with that of the global PIONEER trials and with the safety profile of the GLP-1RA drug class, it is reasonable to assume that long-term safety in this population may be consistent with that seen in the long-term global trials