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Patients are advised to follow the dose escalation schedule closely and not to suddenly jump to higher doses, as this is when side effects like nausea can become pronounced

Crefcoeur LL, Melles MC, Bruning TA, et al

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In addition to its role in purine catabolism, XOR exhibits nitrite reductase activity to produce nitric oxide and NADH oxidase activity to generate ROS under hypoxic, acidic, and inflammatory conditions [14]

Safety: most dogs tolerate it well, but digestive upset can happen start low, give with food, and pause if anything seems off