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Wise, Long-term neurologic consequences of nutritional vitamin B12 deficiency in infants, The Journal of Pediatrics, Volume 121, Issue 5, 1992, Pages 710-714, ISSN 0022-3476, Bell, D

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Low NAD+ links to age-related diseases like cardiovascular issues, metabolic disorders, neurodegeneration, and cancer.[3][16] For example, in Alzheimer's models, NAD+ depletion exacerbates amyloid plaque formation and neuronal death