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A consistent model goes with ligation leading to vessel injury, exposure of tissue factors, stasis, thrombosis, hemodynamic changes, arterial hypotension, and in particular, venous hypertension, which approximates values over 20 mm Hg in the inferior caval vein, thereby being roughly four times higher than those in normal rats

Interestingly, this increase of intracellular pH caused less growth attenuation than growth with decreased intracellular pH

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The liver and the gut are connected by the portal vein, creating a continuous feedback loop known as the gut-liver axis