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The sixth coordination site, the center of reactivity, is variable, being a cyano group (-CN), a hydroxyl group (-OH), a methyl group (-CH3) or a 5-deoxyadenosyl group (here the C5 atom of the deoxyribose forms the covalent bond with Co), respectively, to yield the four B12 forms mentioned above
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Two recent meta-analyses that pooled data from patients with end-stage renal disease found no benefit of B-vitamin supplementation on stroke outcomes (34, 35)
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