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Human leptin deficiency caused by a missense mutation: multiple endocrine defects, decreased sympathetic tone, and immune system dysfunction indicate new targets for leptin action, greater central than peripheral resistance to the effects of leptin, and spontaneous correction of leptin-mediated defects

J Neurosci Off J Soc Neurosci 24:63526361

Human studies, on the other hand, indicate that taking acetyl-L-carnitine daily helps reverse the decline in brain function associated with Alzheimers and other brain diseases (x) (xx) (xxx)

B 63 , 8487 (2001)

is supported by the NIHR Oxford Biomedical Research Centre

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