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They reduce the formation of amyloid plaques in the brain, decrease the production of ROS and could be of interest in other situations such as: ischemia-reperfusion injury, atherosclerosis, diabetes, cancer, obesity, platelet aggregation, blood pressure, depigmentation and cardiomyocyte and cardiac hypertrophy (Thandapilly et al., 2011
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Its principal role is reducing neuronal excitability throughout the nervous system
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4 The researchers identify SLC33A1 as a transporter that exports oxidized glutathione, which helps maintain endoplasmic reticulum redox homeostasis (a stable chemical environment needed for accurate protein folding)
It also raises the possibility that FSP1 inhibitors may disrupt multiple parallel antioxidant systems, potentially enhancing therapeutic efficacy in oxidative stress-dependent pathologies, including cancer and degenerative diseases
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