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Sudden caloric restriction and significant weight changes can affect the hypothalamic-pituitary-gonadal axis, potentially causing menstrual irregularities in some women
Acupuncture & electro-therapeutics research
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Across all participants regardless of treatment completion, mean weight loss was 11.1% with orforglipron versus 2.1% with placebo
So it certainly seems like an issue worth following.
Carlsson LMS, Sjholm K, Jacobson P, et al
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