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Research Highlights Metabolic Regulation and Anti-Obesity Effects: Potent inhibition of nicotinamide N-methyltransferase (NNMT) increases cellular NAD and S-adenosylmethionine (SAM) levels, enhances polyamine flux, boosts energy expenditure, and suppresses lipogenesis

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injections of carprofen (5 mg kg 1 , Pfizer) for 3 days and allowed to recover for a minimum of 7 days with daily monitoring of food intake and body weight

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