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Contraindications: Who Shouldnt Use Semaglutide Semaglutide is contraindicated in specific populations: Personal or family history of medullary thyroid carcinoma (MTC) Multiple endocrine neoplasia syndrome type 2 (MEN 2) Previous serious hypersensitivity to semaglutide Pregnancy (should be discontinued at least two months before planned pregnancy) History of pancreatitis Severe gastrointestinal disease Diabetic retinopathy Kidney disease Depression or suicidal behavior: Providers monitor for new or worsening depression or suicidal thoughts and treatment should be discontinued if these symptoms develop Please note that it's highly important to discuss your health history with your healthcare provider before taking a GLP-1, especially if any of the above apply to you
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Moderate alcohol is not contraindicated, but semaglutide can amplify alcohol's effects on blood sugar and on the gut
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Common Pitfalls and How to Avoid Them (Our Team's Advice) We've seen it all
However, the physiological substrates of OCTN1 are still matter of discussion (Pochini et al., 2019 and Table 1)
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