For both receptors monotreme GLP-1 peptides were equipotent with the GLP-1R agonist oxyntomodulin (OXM)
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Typical Dosage : 13 mg/kg/day, divided into 12 doses
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Wegovy Tablets are licensed for adults (18 years and over) for weight management as an adjunct to a reduced-calorie diet and increased physical activity, where there is: An initial Body Mass Index (BMI) of 30 kg/m or greater (obesity), or An initial BMI of 27 kg/m to less than 30 kg/m (overweight) in the presence of at least one weight-related health problem, for example high blood pressure, type 2 diabetes, high cholesterol or obstructive sleep apnoea Efficacy has been demonstrated regardless of age, sex, race, ethnicity, baseline body weight, BMI and level of renal function, though results vary between individuals
Gilbert, Rosenthal, March 2024