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Bupropion: a systematic review and meta-analysis of effectiveness as an antidepressant
Its a small trial with only 1-year follow up and lacking hard endpoints such as hospitalization or cardiovascular deaths, but the results for symptomatic relief and gain in physical activity are certainly very encouraging
Even in patients taking these drugs strictly for weight loss, pre-existing but unnoticed motility issues can exist
Altogether, NRF2 is a transcriptional factor of GCLC, and ACTL6A co-works with NRF2 and affects NRF2 binding to the promoter of GCLC, thereby regulates GCLC expression at the transcriptional level
You can also report suspected side effects directly to the MHRA via the Yellow Card Scheme (yellowcard.mhra.gov.uk)
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