As for the JADER data, adverse event reports from the first quarter of 2004 to the first quarter of 2021 were obtained from the Pharmaceuticals and Medical Devices Agency website ( A total of 693,295 reports were analyzed in this study
Most studies are small-scale, lack robust methodology, or have not been replicated in larger populations
It also avoids digestions breakdown which can strain the intracellular glutathione levels
This helps control acne, improve hormone and promote skin brightness
Nevertheless, combined with the immunofluorescence result at 4 weeks (Figure 4A), it can be confirmed that the AAV transfection was successful and did not affect the conclusion of this study
Most data comes from preclinical studies and off-label observations