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Current evidence suggests a neutral effect on fracture risk , though findings on bone mineral density (BMD) are mixed, with some studies reporting small site-specific decreases during substantial weight loss
However, clinical trials have yielded mixed results, failing to consistently enhance insulin sensitivity in T2DM [205]
Still, for elderly people who are degenerating and have already begun to lose weight, such dieting may no longer be advisable (Wodarek, 2019) (see also section Mitochondrias Oxygen Consumption Benefits the Microbiota)
Those who received a GLP-1 RA were more likely to be obese (BMI 30 kg/m2) compared with those who did not (85% vs 63%
