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END STAGE RENAL PATIENTS ON HEMODIALYSIS Intravenous solution: Initial dose: 10 to 20 mg/kg as a slow 2 to 3 minute bolus injection into the venous return line after each dialysis session Consider therapy for pre-dialysis trough levels of plasma carnitine below normal (40 to 50 micromol/L)
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Nat Rev Endocrinol (2012) 8(12):72842
Phase 1 Trials In a first-in-human, randomized, placebo-controlled, single ascending dose, phase 1 trial in healthy participants, retatrutide demonstrated a favourable safety profile (similar to other incretin-based therapies) and early signs of efficacy with dose-dependent WL [42]
New insight into therapies targeting angiogenesis in hepatocellular carcinoma
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