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10.1016/s0014-2999(97)01033-9 121 SikiricP.SeiwerthS.MiseS.StaresinicM.BedekovicV.ZarkovicN.et al (2003)

Patients frequently report that their worst pain days become more manageable, and the intensity of flare-ups decreases

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The dose administered is dependent on the condition and can be tailored in frequency and amount based on the patients response

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[7] [9] Patients with a history of oxalate nephrolithiasis (kidney stones) or hyperoxaluria should avoid high-dose vitamin C administration, as ascorbic acid is metabolized to oxalate, which may precipitate stone formation or exacerbate renal impairment