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Petersburg Institute of Bioregulation and Gerontology, it has been shown in research models to stimulate protein synthesis in testicular cells, modulate gene expression linked to steroidogenesis, influence stem cell differentiation into functional Leydig-lineage cells, and counteract age-related involution of reproductive tissues

21 On the other hand, a study that followed 4,746 individuals with tinnitus for four years found 18.3% of cases resolved, 9% improved, 9% worsened, and about 64% experienced no change, 22 and a study in which a questionnaire was administered to 528 tinnitus patients found 25% reported the severity of their tinnitus had increased since its onset

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